Caloosahatchee Creeks Preserve is a Lee County Conservation 20/20 preserve, made up of almost 1,300 acres, that is split in half by Interstate 75. Both sides, East and West, have parklike amenities. The Preserve is named after the seven creeks that flow through it into the Caloosahatchee River which is Caloosahatchee Creeks Preserve's southern boundary.