The Church of the Epiphany is a Roman Catholic parish church of the Archidiocese of New York, located at 373 Second Avenue at the corner of East 22nd Street in the Gramercy Park neighborhood of Manhattan, New York City. The parish was established in 1868. The church was designed by Belfatto & Pavarini and built in 1965-67 for $1,200,000, replacing an earlier church of the same name designed by Napoleon LeBrun and built in 1869-70, which burnt down in December 1963. A four-story brick rectory had been built at 239 East 21st Street in 1936, designed by Robert J. Reiley.