Clarke County is a county of the U.S. state of Alabama. As of the 2010 census, the population was 25,833. The county seat is Grove Hill. The county was created by the legislature of the Mississippi Territory in 1812. It is named in honor of General John Clarke of Georgia, who was later elected governor of that state.The county museum is housed in the Alston-Cobb House in Grove Hill.HistoryPre-European eraFor thousands of years, this area was occupied along the rivers by varying cultures of indigenous peoples. At the time of European encounter, Clarke County was the traditional home of the Choctaw and the Creek people. They traded with the French, who had settlements in Mobile and New Orleans. They also were reached by some English and Scots traders from the British colonies along the Atlantic Coast. After the Louisiana Purchase, they started to establish relations with the United States.In 1805, by the Treaty of Mount Dexter, the Choctaw conveyed large amounts of land in what is now southeastern Mississippi and southwestern Alabama, including much of the western portion of Clarke County, to the United States for settlement by European Americans.