Welcome to the modern Hampton Inn & Suites San Luis Obispo hotel, conveniently located off Highway 101 and Los Osos Valley Road. We are positioned in the heart of Central California, close to Avila Beach, championship golf courses, wine country and only four miles to Cal Poly. Enjoy fishing, hiking, surfing or kayaking at Avila Beach. Take the children to San Luis Obispo Children's Museum or the SLO Museum of Art. Find hunting, jogging and horseback riding only minutes away from our hotel. Traveling on business? This hotel in San Luis Obispo, California is only a few minutes away from California Polytechnic State University and French Hospital.