Keystone Building is a historic commercial building located at Harrisburg, Dauphin County, Pennsylvania. It was built in 1875, as the State Printing Office. It is a six-story office building, plus basement, 7 bays wide and 12 bays deep. It is faced in granite on the first floor, with brick above. It was remodeled in 1917, with the addition of a structural steel frame and 12 inch reinforced floors.It was added to the National Register of Historic Places in 1979.