Lewis County is a county in the U.S. state of West Virginia. As of the 2010 census, the population was 16,372. Its county seat is Weston. The county was formed in 1816 from Harrison County.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (1.2%) is water.Major highways20px Interstate 7920px U.S. Highway 1920px U.S. Highway 4820px23px U.S. Highway 33/U.S. Highway 11920px West Virginia Route 4Adjacent countiesHarrison County (north)Upshur County (east)Webster County (south)Braxton County (southwest)Gilmer County (west)Doddridge County (northwest)