Lowndes County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 59,779. Its county seat is Columbus. The county is named for U.S. Congressman William Jones Lowndes.Lowndes County comprises the Columbus, MS Micropolitan Statistical Area. Since the late 20th century, it has been designated as one of three counties in the Golden Triangle region of the state.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (2.1%) is water.Major highways19px U.S. Highway 4519px U.S. Highway 45 Alternate19px U.S. Highway 8219px Mississippi Highway 1219px Mississippi Highway 5019px Mississippi Highway 6921px Mississippi Highway 182