Mesa County is one of the 64 counties of the U.S. state of Colorado. As of the 2010 census, the population was 146,723. The county seat is Grand Junction. The county was named for the many large mesas in the area, including Grand Mesa.Mesa County comprises the Grand Junction, CO Metropolitan Statistical Area.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (0.4%) is water. It is the fourth-largest county by area in Colorado.Adjacent counties Garfield County – north Pitkin County – east Gunnison County – east Delta County – southeast Montrose County – south Grand County, Utah – westNational protected areasBlack Ridge Canyons WildernessColorado National MonumentDominguez Canyon WildernessDominguez-Escalante National Conservation Area (part)Grand Mesa National ForestManti-La Sal National ForestMcInnis Canyons National Conservation Area (part)Uncompahgre National ForestWhite River National Forest