The Nisqually National Wildlife Refuge is a wildlife preserve operated by the United States Fish and Wildlife Service on the Nisqually River Delta near Puget Sound in northeastern Thurston County, Washington and northwestern Pierce County, Washington. The refuge is located just off Interstate 5, between the cities of Tacoma and Olympia.
The 12.6 km² refuge was created in 1974 to provide habitat and nesting areas for waterfowl and other migratory birds. It includes a protected estuary, salt marshes and open mudflats, freshwater marshes, open grassland, and riparian woodland and brush. An additional 3.2 square kilometres is protected by the disjoint Black River Unit on a tributary of the Chehalis River.