Orangeburg Downtown Historic District is a national historic district located at Orangeburg, Orangeburg County, South Carolina. The district encompasses 44 contributing buildings in the central business district of Orangeburg. It includes a variety of commercial, industrial, and governmental buildings built between about 1883 and 1925. Notable buildings include St. Paul's Methodist Church, U. S. Post Office, Blythewood Building, Orangeburg City Hall, and Fire Department Headquarters.It was added to the National Register of Historic Places in 1985.