San Antonio, or unofficially San Ann as the locals call it, is a city in Pasco County, Florida, United States. It is a suburban city included in the Tampa-St. Petersburg-Clearwater, Florida Metropolitan Statistical Area. It lies within Florida's 5th congressional district. The population was 1,138 at the 2010 census. It was established as a Catholic colony by Judge Edmund F. Dunne. The city derives its name from Saint Anthony of Padua.Saint Leo University is located nearby.GeographySan Antonio is located at .According to the United States Census Bureau, the village has a total area of 1.2sqmi, all land.