Ashland, the largest city in Boyd County, is located upon the southern bank of the Ohio River. The population was 21,684 to the most recent US Census survey. Ashland is a part of the Huntington-Ashland-Ironton metropolitan area. As of the 2010 census, this metropolitan statistical area (MSA) had a population of 287,702. New definitions from February 28, 2013 placed the population at 363,000. Ashland is the second-largest city within the MSA, after Huntington, West Virginia. Ashland serves as an important economic and medical center for northeast Kentucky and is part of the fifth-largest metropolitan area in Kentucky.